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When Ebola kills and when it doesn’t

August 31, 2011

The beginning of fall semester means several things for me:

(1) There are no spaces on the bottom level of the parking garage, and now I have to park on the roof.

(2) Crowded halls

(3) Special seminars

It is the third item which is the subject of this post. Today I heard Manisha Gupta from the CDC speak about her work with Ebola virus. There are multiple Ebola virus species, and most are fatal in the majority of infected persons. However, Bundibugyo ebolavirus infection has a much lower fatality rate, especially when compared to Zaire ebolavirus. Gupta compared virus replication and immune responses in Bundibugyo and Zaire ebolavirus infections to determine the basis for the difference in fatality rates between these two species. Conclusions drawn from this study, referenced below, are presented in the boxed list to the left.


Gupta, M., Goldsmith, C., Metcalfe, M., Spipopoulou, C., & Rollin, P. (2010). Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirus Virology, 402 (1), 203-208 DOI: 10.1016/j.virol.2010.03.024

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